Raymond Michel Schiffelers

NEO-AAV: an engineered extracellular vesicle-enveloped AAV platform for activation-coupled T cell transduction and CAR-T cell generation

This paper introduces NEO-AAV, an engineered AAV platform that enhances T cell transduction and CAR-T cell generation by enveloping AAV in extracellular vesicles, improving immune resistance and transduction efficiency.

An extracellular vesicle biogenesis-inspired engineering platform for efficient protein delivery and therapeutic base editing

This paper introduces a platform for efficient protein delivery using extracellular vesicles engineered with biogenesis-inspired features, achieving functional gene editing in vitro and in vivo.

Chiral Histidine-Modified Gold Nanoclusters Loaded into Cationic Lipid Nanoparticles for Treatment of Biofilm-associated Infections

This paper develops chiral histidine-modified gold nanoclusters encapsulated in cationic lipid nanoparticles to treat biofilm-associated infections, showing enhanced efficacy in reducing bacterial burden and biomass.

A modular strategy for extracellular vesicle-mediated CRISPR-Cas9 delivery through aptamer-based loading and UV-activated cargo release

This paper develops a modular strategy for delivering CRISPR-Cas9 via extracellular vesicles using aptamer-based loading and UV-activated cargo release, demonstrating efficient delivery and versatility in Cas9 variants.

Liposomal encapsulation of L-arginine and L-citrulline enhances therapeutic effects in a rat model of Preeclampsia and Fetal Growth Restriction

This study shows that liposomal encapsulation of L-arginine and L-citrulline improves pharmacokinetics and reduces maternal blood pressure in a rat model of Preeclampsia and Fetal Growth Restriction.

RUNX1::RUNX1T1 Depletion Eliminates Stemness and Induces Bidirectional Differentiation of Acute Myeloid Leukemia

This study shows that depletion of RUNX1::RUNX1T1 in AML cells reduces stemness and promotes differentiation into granulocytic and eosinophilic/mast cell-like populations.