Zhiyong Lei

This study shows that the PLN R14del mutation increases nuclear susceptibility to mechanical stress in cardiomyopathy, linking nuclear dysfunction to disease variability.

This paper introduces NEO-AAV, an engineered AAV platform that enhances T cell transduction and CAR-T cell generation by enveloping AAV in extracellular vesicles, improving immune resistance and transduction efficiency.

This paper introduces a platform for efficient protein delivery using extracellular vesicles engineered with biogenesis-inspired features, achieving functional gene editing in vitro and in vivo.

This paper develops chiral histidine-modified gold nanoclusters encapsulated in cationic lipid nanoparticles to treat biofilm-associated infections, showing enhanced efficacy in reducing bacterial burden and biomass.