Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation
Erika Lazzarin, Ralph Gradisch, Sophie M.C. Skopec, Letícia Alves da Silva, Chiara Sebastianelli-Schoditsch, Dániel Szöllősi, Julian Maier, Sonja Sučić, Marko Roblek, Baruch I. Kanner, Harald H. Sitte, Thomas Stockner
This study identifies a novel sodium recruiting site in GAT1 and shows how sodium binding stabilizes the transporter's conformation and enhances GABA uptake.
bioRxiv · Oct 10, 2023 · PreprintMolecular Biology