Harald H. Sitte

This study evaluates three MDMA bioisosteres for improved pharmacological profiles, finding reduced off-target receptor activity and altered hepatic metabolism compared to MDMA.

This study identifies betaine as a slow substrate of GAT1, showing it modulates GABA reuptake and helps maintain GABA homeostasis, protecting neurons from excitotoxicity.

This study identifies a novel sodium recruiting site in GAT1 and shows how sodium binding stabilizes the transporter's conformation and enhances GABA uptake.

This study investigates the role of Ric GTPase in dopamine transporter function and behavior in Drosophila, finding that RicQ117L affects DAT trafficking and amphetamine sensitivity in a DAT-dependent manner.

This study investigates the role of Rit2 GTPase in PKC-stimulated dopamine transporter (DAT) endocytosis in DAergic terminals, revealing region- and sex-specific differences.