Author

Ralph Gradisch

Medical University of ViennaORCID 0000-0002-3312-2472Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Erika LazzariniD· 2 shared Harald H. SitteiD· 2 shared Thomas StockneriD· 2 shared Ana Sofia Alberto‐SilvaiD· 1 shared Andre BazzoneiD· 1 shared Baruch I. Kanner· 1 shared Chiara Sebastianelli-SchoditschiD· 1 shared Dániel SzöllősiiD· 1 shared

Activity by Year

2023-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersNeuroscience

Erika LazzarinORCID

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2 papers

Recent·Most cited

Unveiling the crucial role of betaine: Modulation of GABA homeostasis via SLC6A1 transporter (GAT1)

Manan Bhatt, Erika Lazzarin, Ana Sofia Alberto‐Silva, Guido Domingo, Rocco Zerlotti, Ralph Gradisch, Andre Bazzone, Harald H. Sitte, Thomas Stockner, Elena Bossi

This study identifies betaine as a slow substrate of GAT1, showing it modulates GABA reuptake and helps maintain GABA homeostasis, protecting neurons from excitotoxicity.

Cellular and Molecular Life Sciences · Jun 17, 2024Peer-reviewedNeuroscience

Interaction of GAT1 with sodium ions: from efficient recruitment to stabilisation of substrate and conformation

Erika Lazzarin, Ralph Gradisch, Sophie M.C. Skopec, Letícia Alves da Silva, Chiara Sebastianelli-Schoditsch, Dániel Szöllősi, Julian Maier, Sonja Sučić, Marko Roblek, Baruch I. Kanner, Harald H. Sitte, Thomas Stockner

This study identifies a novel sodium recruiting site in GAT1 and shows how sodium binding stabilizes the transporter's conformation and enhances GABA uptake.

bioRxiv · Oct 10, 2023 · PreprintMolecular Biology