Autophagy suppression in DNA damaged cells occurs through a newly identified p53-proteasome-LC3 axis
D’Feau J. Lieu, Molly K. Crowder, Jordan R. Kryza, Batcha Tamilselvam, Paul J. Kaminski, Ik-Jung Kim, Yingxing Li, Eunji Jeong, Michidmaa Enkhbaatar, Henry Chen, Sophia B. Son, Hanlin Mok, Kenneth A. Bradley, Heidi Phillips, Steven R. Blanke
The paper identifies a p53-proteasome-LC3 axis that suppresses autophagy in DNA damaged cells, linking p53 stabilization to reduced LC3A/B levels.
iScience · Feb 27, 2025Peer-reviewedCell Biology