Architecture of a DNA-guided Cas12a
Rodrigo Fregoso Ocampo, Carlos Orosco, Boyu Huang, Madeline S. West, Bay Parker, Piyush Jain, David Ward Taylor
The paper presents the cryo-EM structure of AsCas12a bound to a pseudo-DNA guide and RNA target, revealing its mechanism of DNA-guided RNA recognition.
Nature Structural & Molecular Biology · Sep 9, 2026Peer-reviewedBiochemistry