Interrogation of genome-wide, experimentally dissected gene regulatory networks reveals mechanisms underlying dynamic cellular state control
Xiangtian Tan, Jeremy Worley, Mikko M. Turunen, Kelly Wong, Ester Calvo Fernández, Evan Paull, Sunny J. Jones, Junqiang Wang, Heeju Noh, Beatrice Salvatori, Alejandro Chavez, Andrea Califano
The paper uses CRISPRi and single-cell RNA-seq to reverse engineer gene regulatory networks in colorectal cancer cells, revealing autoregulatory and cooperative mechanisms.
bioRxiv · Jun 28, 2021 · PreprintSystems Biology