DNA writing at a single genomic site enables lineage tracing and analog recording in mammalian cells
Theresa B. Loveless, Joseph H. Grotts, Mason W. Schechter, Elmira Forouzmand, Courtney K. Carlson, Bijan S. Agahi, Guohao Liang, Michelle Ficht, Beide Liu, Xiaohui S. Xie, Chang C. Liu
This paper introduces CHYRON, a DNA recorder that writes new DNA to track lineage and record cellular stimuli, demonstrating its ability to reconstruct lineage relationships and respond to stress signals.
Nature Chemical Biology · Mar 22, 2021Peer-reviewedSynthetic Biology