Synthetic microbial sensing and biosynthesis of amaryllidaceae alkaloids
Simon d’Oelsnitz, Daniel J. Diaz, Wantae Kim, Daniel J. Acosta, Tyler L. Dangerfield, Mason W. Schechter, Matthew B. Minus, James R. Howard, Hannah Do, James M. Loy, Hal S. Alper, Yan Zhang, Andrew D. Ellington
The paper develops a biosensor-AI system to engineer E. coli for efficient production of amaryllidaceae alkaloids, achieving improved titer and reduced byproducts.
Nature Communications · Mar 7, 2024Peer-reviewedSynthetic Biology