Author

Michelle Ficht

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Synthetic Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:cell-cell communication· 2 Assay:DNA methylation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Research Focus:trajectory inference· 2 Assay:CRISPR screen· 1

Frequent Co-Authors

Chang C. LiuiD· 2 shared Courtney K. CarlsoniD· 2 shared Guohao Liang· 2 shared Theresa B. LovelessiD· 2 shared Ali Murtaza· 1 shared Arushi Singhai· 1 shared Beide Liu· 1 shared Bijan S. Agahi· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersGenetics

Chang C. LiuORCID

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Author profile →

2 papers

Recent·Most cited

Open-ended molecular recording of sequential cellular events into DNA

Theresa B. Loveless, Courtney K. Carlson, Catalina A. Dentzel Helmy, Vincent J. Hu, Sara K. Ross, Matt C. Demelo, Ali Murtaza, Guohao Liang, Michelle Ficht, Arushi Singhai, Marcello Pajoh-Casco, Chang C. Liu

This paper introduces peCHYRON, a DNA recorder that sequentially records cellular events in mammalian cells using prime editing, enabling durable, high-information, and temporally resolved molecular recording.

Nature Chemical Biology · Nov 14, 2024Peer-reviewedGenetics

DNA writing at a single genomic site enables lineage tracing and analog recording in mammalian cells

Theresa B. Loveless, Joseph H. Grotts, Mason W. Schechter, Elmira Forouzmand, Courtney K. Carlson, Bijan S. Agahi, Guohao Liang, Michelle Ficht, Beide Liu, Xiaohui S. Xie, Chang C. Liu

This paper introduces CHYRON, a DNA recorder that writes new DNA to track lineage and record cellular stimuli, demonstrating its ability to reconstruct lineage relationships and respond to stress signals.

Nature Chemical Biology · Mar 22, 2021Peer-reviewedSynthetic Biology