Author

Guohao Liang

University of California, Irvine

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 1 Molecular Biology· 1 Synthetic Biology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell-cell communication· 2 Assay:DNA methylation· 2 Research Focus:gene regulatory network inference· 2 Research Focus:trajectory inference· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

Chang C. LiuiD· 2 shared Courtney K. CarlsoniD· 2 shared Fangyuan DingiD· 2 shared Michelle Ficht· 2 shared Theresa B. LovelessiD· 2 shared Ali Murtaza· 1 shared Arushi Singhai· 1 shared Beide Liu· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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2 shared papersGenetics

Chang C. LiuORCID

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Author profile →

4 papers

Recent·Most cited

Single-probe, high-yield spatial mapping of diverse short RNA motifs

Guohao Liang, Kenneth N Joseph, Kayleigh Sim, Vadym Kuchumov, Zhiqun Tan, Xiangmin Xu, Fangyuan Ding

The paper introduces SMOOTHY-FISH, a method to visualize short RNA motifs at single-molecule resolution, revealing new spatial RNA biology insights in single cells and mouse brain tissues.

bioRxiv · Nov 4, 2026 · PreprintMolecular Biology

Open-ended molecular recording of sequential cellular events into DNA

Theresa B. Loveless, Courtney K. Carlson, Catalina A. Dentzel Helmy, Vincent J. Hu, Sara K. Ross, Matt C. Demelo, Ali Murtaza, Guohao Liang, Michelle Ficht, Arushi Singhai, Marcello Pajoh-Casco, Chang C. Liu

This paper introduces peCHYRON, a DNA recorder that sequentially records cellular events in mammalian cells using prime editing, enabling durable, high-information, and temporally resolved molecular recording.

Nature Chemical Biology · Nov 14, 2024Peer-reviewedGenetics

Dynamics and functional roles of splicing factor autoregulation

Fangyuan Ding, Christina J. Su, KeHuan Kuo Edmonds, Guohao Liang, Michael B. Elowitz

This study investigates the dynamics and functional roles of negative autoregulation by the SF2 splicing factor in single cells, showing its role in regulating protein concentration and reducing cell-to-cell variability.

Cell Reports · Jun 1, 2022Peer-reviewedSystems Biology

DNA writing at a single genomic site enables lineage tracing and analog recording in mammalian cells

Theresa B. Loveless, Joseph H. Grotts, Mason W. Schechter, Elmira Forouzmand, Courtney K. Carlson, Bijan S. Agahi, Guohao Liang, Michelle Ficht, Beide Liu, Xiaohui S. Xie, Chang C. Liu

This paper introduces CHYRON, a DNA recorder that writes new DNA to track lineage and record cellular stimuli, demonstrating its ability to reconstruct lineage relationships and respond to stress signals.

Nature Chemical Biology · Mar 22, 2021Peer-reviewedSynthetic Biology