CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythms
Yao D. Cai, Yongbo Xue, Cindy C. Truong, Jose Del Carmen-Li, Christopher J Ochoa, Jens T. Vanselow, Katherine A. Murphy, Ying H. Li, Xianhui Liu, Ben L. Kunimoto, Haiyan Zheng, Caifeng Zhao, Yong Zhang, Andreas Schlösser, Joanna C. Chiu
The paper identifies TIM phosphorylation sites in Drosophila and shows that CK2-dependent phosphorylation of TIM(S1404) regulates nuclear export and circadian rhythms, with implications for human FASPS.
Current Biology · Nov 19, 2020Peer-reviewedNeuroscience