Yao D. Cai

Splicing of a core clock gene regulates seasonal adaptations by a winter gating mechanism

This study shows that alternative splicing of the timeless gene regulates seasonal adaptations in Drosophila by modulating PDF signaling through a winter gating mechanism.

Mealtime alters daily rhythm in nuclear O-GlcNAc proteome to regulate hepatic gene expression

This study shows that mealtime affects the daily rhythm of nuclear O-GlcNAc proteome in mice, which regulates hepatic gene expression through interactions with phosphorylation.

Alternative splicing of clock transcript mediates the response of circadian clocks to temperature changes

The paper investigates temperature-sensitive alternative splicing of the clk gene in Drosophila and its role in regulating circadian clock function through phosphorylation site deletion.

CLOCK and TIMELESS regulate rhythmic occupancy of the BRAHMA chromatin-remodeling protein at clock gene promoters

This study shows CLOCK and TIMELESS regulate daily rhythmic BRM chromatin-remodeling activity at clock gene promoters in Drosophila.

PERIOD phosphoclusters control temperature compensation of the Drosophila circadian clock

This paper identifies the role of PER phosphodegron residues in temperature compensation of the Drosophila circadian clock through genetic and biochemical experiments.

CK2 inhibits TIMELESS nuclear export and modulates CLOCK transcriptional activity to regulate circadian rhythms

The paper identifies TIM phosphorylation sites in Drosophila and shows that CK2-dependent phosphorylation of TIM(S1404) regulates nuclear export and circadian rhythms, with implications for human FASPS.

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance

This study identifies DOM splice variants DOM-A and DOM-B as regulators of circadian behavior and sLNv maintenance in Drosophila by modulating pacemaker gene expression and PDF accumulation.