Colorectal cancer progression to metastasis is associated with dynamic genome-wide biphasic 5-hydroxymethylcytosine accumulation.
Ben Murcott, Floris Honig, Dominic Oliver Halliwell, Yuan Tian, Joanne L. Robson, Piotr J. Manasterski, Jennifer Pinnell, Thérèse Dix‐Peek, Santiago Uribe‐Lewis, Ashraf E.K. Ibrahim, Julia Sero, David Gurevich, Nikolas Nikolaou, Adele Murrell
This study shows that 5-hydroxymethylcytosine (5hmC) levels increase in liver metastases compared to primary colon tumors and is linked to TET2/TET3 expression and migration-related pathways.
BMC Biology · Apr 16, 2025Peer-reviewedCancer Biology