BRD2 bridges TFIID and histone acetylation to promote transcriptional initiation
Bin Zheng, Ruxuan Qiu, Sarah R. Gold, Marta Iwanaszko, Yuki Aoi, Benjamin Charles Howard, Madhurima Das, Ali Shilatifard
This study shows BRD2 promotes transcriptional initiation via bromodomain-dependent binding to acetylated histones and recruits TFIID, while BRD4 mediates elongation through CDK9 recruitment.
bioRxiv · Sep 20, 2025 · PreprintBiochemistry