Yuki Aoi

This study identifies MeCP2's interaction with the super elongation complex and shows it regulates transcription by modulating RNA polymerase II binding and gene expression.

This study shows BRD2 promotes transcriptional initiation via bromodomain-dependent binding to acetylated histones and recruits TFIID, while BRD4 mediates elongation through CDK9 recruitment.

The paper identifies ELOA-dependent mechanisms regulating transcription maturation and links them to cellular senescence and aging through RNA processing defects and growth arrest.

This study shows that NELF-C loss disrupts Pol II transcription termination and causes transcription-replication conflicts in colorectal cancer.

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.