Ali Shilatifard

POU2AF2/OCA-T1 coactivates POU2F2 and defines a lineage-specific dependency in diffuse large B-cell lymphoma

This study identifies POU2AF2 as a lineage-specific dependency in DLBCL, showing it coactivates POU2F2 to sustain malignant transcriptional networks and innate-like B-cell identity.

FCD-11: A First-in-Class COMPASS Inhibitor in Cancer Therapeutics

The paper identifies and characterizes FCD-11, a first-in-class COMPASS inhibitor that reduces tumor size and extends survival in breast cancer models.

MeCP2 Interacts with the Super Elongation Complex to Regulate Transcription

This study identifies MeCP2's interaction with the super elongation complex and shows it regulates transcription by modulating RNA polymerase II binding and gene expression.

BRD2 bridges TFIID and histone acetylation to promote transcriptional initiation

This study shows BRD2 promotes transcriptional initiation via bromodomain-dependent binding to acetylated histones and recruits TFIID, while BRD4 mediates elongation through CDK9 recruitment.

Transcriptional Elongation-Associated RNA Processing Errors in Induced Cellular Growth Arrest

The paper identifies ELOA-dependent mechanisms regulating transcription maturation and links them to cellular senescence and aging through RNA processing defects and growth arrest.

NELF coordinates Pol II transcription termination and DNA replication initiation

This study shows that NELF-C loss disrupts Pol II transcription termination and causes transcription-replication conflicts in colorectal cancer.

LEDGF and HDGF2 relieve the nucleosome-induced barrier to transcription

The paper identifies LEDGF and HDGF2 as proteins that substitute for FACT in differentiated tissues to enable RNAPII to overcome nucleosome barriers during transcription.

Single-Cell Transcriptomic Analysis of Human Lung Reveals Complex Multicellular Changes During Pulmonary Fibrosis

Single-cell RNA-seq of lung tissue from transplant donors, fibrosis patients, and a living patient identifies cell type-specific disease-associated molecular pathways in pulmonary fibrosis.