Baseline expression of c-Myc defines the tissue specificity of oncogenic K-Ras
Olesja Popow, Qing Yu, Clarence Yapp, Shannon Hull, João A. Paulo, Benjamin Hanna, Shidong Xu, Yanan Kuang, Carlie Sigel, Cloud Peter Paweletz, Steven P. Gygi, Kevin M. Haigis
The paper shows that low baseline c-Myc expression restricts oncogenic K-Ras activity in tissues, and this can be reversed by increasing c-Myc in the liver.
bioRxiv · Jul 21, 2025 · PreprintCancer Biology