S1P induces bleb-based T cell motility via S1PR1-dependent activation of RhoA and WNK1
Franklin D. Staback Rodriguez, Henry De Belly, Yichen Zhang, Evelyn Strickland, Gordon L. Frazer, Judith Ojukwu, Benjamin J. Williamson, Orion David Weiner, Janis K. Burkhardt
This study identifies that S1P induces T cell motility through sustained RhoA activation and WNK1-dependent water influx, leading to bleb-based movement.
bioRxiv · Oct 3, 2025 · PreprintCell Biology