Orion David Weiner

This paper develops a cell-machine interface to program collective cell migration by rewriting cell-cell interaction rules using optogenetic control and computer vision.

This study shows neutrophils maintain high migration speed in capillaries of varying sizes by adapting their actomyosin cytoskeleton via the ROCK-MyoII pathway, preventing vascular obstruction.

The paper models neutrophil navigation through complex chemical gradients using reaction-diffusion equations for Rac and Rho, showing that feedback mechanisms improve motility through narrow and convoluted paths.

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

The paper reveals a long-range mutual activation mechanism between Rho and Rac GTPases that establishes polarity during cell migration, conserved in epithelial cells and essential for T cell migration.

This study identifies arachidonic acid (AA) as a key regulator of neutrophil swarming, showing that AA release is necessary and sufficient for swarm initiation and scaling.

This study shows that Myosin1E adapts to increased membrane tension by recruiting to more clathrin-mediated endocytosis sites to enhance actin network formation and promote internalization.

The paper extends mathematical models of cell migration by incorporating local negative feedback of Rac activity, showing improved response to dynamic guidance cues and noisy gradients.

This study identifies that S1P induces T cell motility through sustained RhoA activation and WNK1-dependent water influx, leading to bleb-based movement.

This study identifies a mechanical defect in embryos from aged mothers that impairs implantation, showing increased trophectoderm contractility leads to defective spreading during implantation.

This study shows YAP and Mediator form transcriptionally active condensates through charge patterning, enabling signal integration in stem cells.

This study shows the WAVE complex forms linear arrays at negative membrane curvature to instruct lamellipodia formation through in vivo biochemical approaches.

This paper describes a computational method for designing -helical-barrel proteins with small molecule-binding channels, achieving high expression and structural accuracy in E. coli.

The paper designs synthetic proteins by deriving sequence-to-structure rules from coiled-coil tetramers and validates them through experimental methods.

This study uses live-cell imaging to show that Sox2 transcription occurs without requiring enhancer proximity in embryonic stem cells.

The paper investigates signal amplification in the B cell Ras/MAPK pathway, finding multiple sources of digital responses independent of positive feedback.

The paper shows chick cranial neural crest cells migrate by progressively refining protrusion polarity, with orientation guiding protrusion selection.