Henry De Belly

This study shows neutrophils maintain high migration speed in capillaries of varying sizes by adapting their actomyosin cytoskeleton via the ROCK-MyoII pathway, preventing vascular obstruction.

The paper models neutrophil navigation through complex chemical gradients using reaction-diffusion equations for Rac and Rho, showing that feedback mechanisms improve motility through narrow and convoluted paths.

The paper identifies ERGU-1 as a conserved antioxidant protein at ER membranes using AlphaFold2 and functional screens in C. elegans, showing its role in H2O2 detoxification and antioxidant defense.

The paper reveals a long-range mutual activation mechanism between Rho and Rac GTPases that establishes polarity during cell migration, conserved in epithelial cells and essential for T cell migration.

This study identifies arachidonic acid (AA) as a key regulator of neutrophil swarming, showing that AA release is necessary and sufficient for swarm initiation and scaling.

This study shows that Myosin1E adapts to increased membrane tension by recruiting to more clathrin-mediated endocytosis sites to enhance actin network formation and promote internalization.

This study identifies that S1P induces T cell motility through sustained RhoA activation and WNK1-dependent water influx, leading to bleb-based movement.

The paper identifies dynamic cell surface fluctuations as a key factor in early embryonic lineage sorting, showing that increased surface fluctuations in primitive endoderm precursors drive their segregation from epiblast precursors.