PAX3-FOXO1 drives targetable cell state-dependent metabolic vulnerabilities in rhabdomyosarcoma
Katrina I. Paras, Julia S. Brunner, Jacob A. Boyer, Angela M. Montero, Benjamin T. Jackson, Sangita Chakraborty, Abigail Xie, Kristina C. Guillan, Armaan H. Siddiquee, Lourdes Pajuelo Torres, Joshua D. Rabinowitz, Andrew L. Kung, Daoqi You, Filemon S. Dela Cruz, Lydia W.S. Finley
This study shows that PAX3-FOXO1 drives metabolic vulnerabilities in rhabdomyosarcoma, making these cells sensitive to methotrexate.
Cancer Research · Sep 5, 2025Peer-reviewedCancer Biology