Gregory J. Hannon

This paper introduces a 3D imaging pipeline to detect functionally perfused vasculogenic mimicry in mouse tumor models, providing evidence of its presence and functionality.

This study uses graph theory and imaging techniques to analyze vasculogenic mimicry in vitro and in vivo, showing its association with oxygenation heterogeneity and resistance to anti-angiogenic treatment.

This study analyzes the evolutionary patterns of Gypsy-family LTR retrotransposons across 249 Drosophila genomes, revealing shifts in regulatory mechanisms and transcription factor involvement.

This study uses spatial transcriptomic and proteomic profiling to identify cell interaction patterns that predict progression of Barrett's esophagus.

This study identifies Traffic jam as a master regulator of the somatic piRNA pathway in Drosophila ovaries, showing its role in controlling piRNA factors and the flamenco cluster.

The paper benchmarks CRISPR sgRNA design algorithms and creates smaller, efficient libraries for loss-of-function screens.

This paper develops an in silico model to predict personalized therapeutic combinations for NSCLC by simulating genetic profiles and testing drug combinations to overcome resistance.

The paper introduces BALI, a method for spatially tuneable multi-omic profiling using light-driven combinatorial barcoding, demonstrating its application on mouse brain tissue.

FlaHMM automates the identification of piRNA clusters in Drosophila species using hidden Markov models and genome sequence data alone.

This study identifies Ovo as the master regulator of the germline piRNA pathway in Drosophila ovaries, showing its role in activating pathway components and binding to promoter motifs.

The paper identifies a dual histone modification (H3K9me3 and H3K27me3) that specifies Rhino binding to a subset of piRNA source loci in Drosophila germ cells, independent of Kipferl.

The paper identifies five additional flam-like piRNA clusters across 119 Drosophila species, showing conserved transposon silencing mechanisms in somatic ovarian cells.

The paper introduces a dual-modality imaging method combining high-resolution immunofluorescence and imaging mass cytometry to generate whole-slide IMC images with accurate single-cell segmentation.

The paper identifies a conserved stop codon enrichment at the 5' ends of mammalian piRNAs, revealing Zuc-dependent cleavage preferences and a potential link to translational machinery.

The paper identifies potent siRNAs against SARS-CoV-2 through RNAi screening, validates their efficacy against variants, and demonstrates their prophylactic potential in a hamster model.

The paper investigates the role of maternally inherited piRNAs in silencing transposons in early Drosophila embryos by analyzing their impact on heterochromatin formation and transposon expression.

This study identifies LC8/Cut-up as an essential component of the PICTS complex in Drosophila, showing its role in transposon silencing through complex dimerisation.

ExSeq enables multiplexed RNA mapping at nanoscale resolution by expanding biological specimens for in situ sequencing.

The paper shows GCNA interacts with Topoisomerase II to resolve DNA-protein crosslinks, maintaining genome stability in germline and early embryos.

This study identifies Nxf3 as essential for exporting piRNA precursors from dual-strand clusters in Drosophila, ensuring proper piRNA production and transposon silencing.

The paper identifies Nxf2 and Nxt1 as factors required for piRNA-guided co-transcriptional silencing of transposons in Drosophila, showing their interaction with Panx and role in repressive chromatin formation.

The paper identifies Daedalus and Gasz as mitochondrial factors that recruit Armitage to mitochondria, facilitating piRNA precursor processing by linking nuage/Yb-body and mitochondrial biogenesis machinery.

The paper identifies lncRNA Spehd as essential for hematopoietic stem cell differentiation and multilineage potential in mice.

This paper introduces SmartCodes, functionalized barcodes that allow targeted retrieval and manipulation of clonal lineages in heterogeneous populations using CRISPR-based readers.