M. Joaquina Delàs

Minimal essential requirements for neural tube self-organisation

The paper shows that RA induces a transient co-expression state of PAX6 and FOXA2 in neural tube organoids, leading to two opposing cell fates that determine cell-type proportions through feedback signaling.

Lineage-specific retrotransposon co-option reveals a conserved ASH2L isoform as an epigenetic primer of developmental gene promoters

The paper shows that a truncated ASH2L isoform, generated via a lineage-specific retrotransposon, primes developmental gene promoters during pluripotency and is required for later developmental transitions.

Reconstructing Waddington's Landscape from Data

This paper introduces a computational framework to reconstruct developmental landscapes from single-cell data, revealing morphogen-dependent cell fate transitions in neural progenitors.

The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube

This study identifies a global temporal chromatin programme in vertebrate neural progenitors that integrates with spatial patterning to regulate cell fate and identity.

Dynamic Landscape Analysis of Cell Fate Decisions: Predictive Models of Neural Development From Single-Cell Data

This paper introduces a framework to model cell fate decisions using single-cell data, revealing conserved decision-making architectures across species.

Predictable Engineering of Signal-DependentCis-Regulatory Elements

The paper develops a method to engineer synthetic cis-regulatory elements that control gene expression in response to signals, showing they can be designed using quantitative rules.

Developmental cell fate choice employs two distinct cis regulatory strategies

The paper identifies two distinct cis regulatory strategies used by CREs to translate graded Shh signaling into differential gene expression in neural progenitors.

Sox2 levels configure the WNT response of epiblast progenitors responsible for vertebrate body formation

The paper shows that Sox2 levels determine how WNT signaling affects epiblast progenitors, influencing pluripotency and mesodermal differentiation through changes in chromatin occupancy and regulatory element selection.

LncRNA Spehd regulates hematopoietic stem cells and progenitors and is required for multilineage differentiation

The paper identifies lncRNA Spehd as essential for hematopoietic stem cell differentiation and multilineage potential in mice.