A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature
Alicia M. Kemble, Benoit Hornsperger, Iris Ruf, Hans Georg Richter, Jörg Benz, Bernd Kuhn, Dominik Heer, Matthias Wittwer, Britta Engelhardt, Uwe Grether, Ludovic Collin
This study characterizes a novel MAGL inhibitor in a mouse model and human cells, showing its expression in neurovascular unit cells but no effect on blood-brain barrier permeability or cytokine production.
PLoS ONE · Sep 9, 2022Peer-reviewedNeuroscience