Ludovic Collin

Single nuclei RNAseq stratifies multiple sclerosis patients into distinct white matter glia responses

The paper uses single nuclei RNAseq to identify distinct glial gene expression patterns in MS patients, revealing subgroup-specific pathological processes and suggesting precision medicine approaches.

An arrayed CRISPR/Cas9 screen identifies mTORC1 as a regulator of lipid droplet accumulation in APOE E3 and APOE KO iPSC-derived microglia

A potent and selective inhibitor for the modulation of MAGL activity in the neurovasculature

This study characterizes a novel MAGL inhibitor in a mouse model and human cells, showing its expression in neurovascular unit cells but no effect on blood-brain barrier permeability or cytokine production.

On the discovery of population-specific state transitions from multi-sample multi-condition single-cell RNA sequencing data

This paper develops a simulation platform and analysis tools for multi-condition differential state analysis in scRNA-seq data, comparing cell-level mixed models and pseudobulk approaches.