Bernd Kuhn

This study evaluates how systemic biases affect scoring function performance in virtual screening, finding that biases can inflate results and that classical methods outperform machine learning models on out-of-distribution targets.

This study shows that low doses of SARM1 base-exchange inhibitors paradoxically increase SARM1 activity and worsen neurodegeneration in vitro and in vivo.

This study characterizes a novel MAGL inhibitor in a mouse model and human cells, showing its expression in neurovascular unit cells but no effect on blood-brain barrier permeability or cytokine production.