Adeno-associated virus (AAV2) can replicate its DNA by a rolling hairpin or rolling circle mechanism, depending on the helper virus.
Anouk Lkharrazi, Kurt Tobler, Sara Marti, Anna Bratus-Neuenschwander, Bernd Vogt, Cornel Fraefel
This study compares AAV2 DNA replication mechanisms under HSV-1 and AdV5 helper virus conditions, finding that HSV-1 supports rolling circle replication while AdV5 supports rolling hairpin replication.
bioRxiv · Nov 13, 2023 · PreprintMolecular Biology