Cornel Fraefel

This study develops and tests a low-stress oral administration method for mice called unconstrained dosing agar (UDA), showing it reduces stress and maintains body weight gain.

This study compares NSP5/VP2-induced viroplasm-like structures across rotavirus species A-J, identifying species-specific differences and conserved mechanisms in VLS formation.

This study identifies the role of AAP's phase separation properties in AAV2 capsid assembly and shows that specific amino acids are critical for this process.

This study examines the formation of viroplasm-like structures (VLS) by co-expressing NSP5 and NSP2 across Rotavirus species A-J, finding species-specific VLS morphology and self-oligomerization properties of NSP5.

The paper identifies IFI16 as a restriction factor for AAV2 transduction that acts independently of immune modulation by interfering with Sp1-dependent promoter activation.

The paper shows that inducing autophagy with hyperosmotic sucrose enhances AAV2 transduction efficiency through a non-canonical pathway, distinct from the PI3K-III-dependent mechanism.

This study compares AAV2 DNA replication mechanisms under HSV-1 and AdV5 helper virus conditions, finding that HSV-1 supports rolling circle replication while AdV5 supports rolling hairpin replication.

The paper investigates AAV2 uncoating and finds it occurs in a stepwise process completed in the nucleolus, with structural reorganization of the nucleolus supporting this process.