Kurt Tobler

Comparative analysis of NSP5/VP2-induced viroplasm-like structures in rotavirus species A to J

This study compares NSP5/VP2-induced viroplasm-like structures across rotavirus species A-J, identifying species-specific differences and conserved mechanisms in VLS formation.

The limited effects of AAV2 vectors on host chromatin accessibility and nuclear architecture are consistent with a favorable safety profile

Characterization of Viroplasm-Like Structures by Co-Expression of NSP5 and NSP2 Across Rotavirus Species A to J

This study examines the formation of viroplasm-like structures (VLS) by co-expressing NSP5 and NSP2 across Rotavirus species A-J, finding species-specific VLS morphology and self-oligomerization properties of NSP5.

Adeno-associated virus (AAV2) can replicate its DNA by a rolling hairpin or rolling circle mechanism, depending on the helper virus.

This study compares AAV2 DNA replication mechanisms under HSV-1 and AdV5 helper virus conditions, finding that HSV-1 supports rolling circle replication while AdV5 supports rolling hairpin replication.