NeurosciencebioRxivPreprint
Inhibition of adenylyl cyclase 1 (AC1) and exchange protein directly activated by cAMP (EPAC) restores ATP-sensitive potassium (KATP) channel activity after chronic opioid exposure
Amanda H. Klein, Sabbir Alam, Kayla Johnson…·Val J. Watts
This study shows that inhibiting AC1 and EPAC restores KATP channel activity after chronic opioid exposure, reducing morphine tolerance and withdrawal.
DOI 10.1101/2025.02.03.636278