Author

Val J. Watts

Purdue University West LafayetteORCID 0000-0003-1581-2936Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Molecular Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:mouse· 3 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Amanda H. KleiniD· 2 shared Hongxia ReniD· 2 shared Jason Michael ConleyiD· 2 shared Kayla JohnsoniD· 2 shared Aleeya Verdi· 1 shared Alexander JochimiD· 1 shared Alexis Doucette· 1 shared Alexis Edwards· 1 shared

Activity by Year

2022-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Amanda H. KleinORCID

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4 papers

Recent·Most cited

Pharmacology & ToxicologyEuropean Journal of Medicinal ChemistryPeer-reviewedMay 22, 2025

Discovery of Novel and Selective GPR17 Antagonists as Pharmacological Tools for Developing New Therapeutic Strategies in Diabetes and Obesity

Hu Zhu, Jason Michael Conley, Karavadhi Surendra…·Samarjit Patnaik

The paper identifies two novel GPR17 antagonists through high-throughput screening that selectively inhibit GPR17 signaling and enhance GLP-1 secretion, offering potential for diabetes and obesity treatment.

12 citations

experimental assaydrug response / drug discovery

𝕏 PostBluesky

NeurosciencebioRxivPreprintFeb 3, 2025

Inhibition of adenylyl cyclase 1 (AC1) and exchange protein directly activated by cAMP (EPAC) restores ATP-sensitive potassium (KATP) channel activity after chronic opioid exposure

Amanda H. Klein, Sabbir Alam, Kayla Johnson…·Val J. Watts

This study shows that inhibiting AC1 and EPAC restores KATP channel activity after chronic opioid exposure, reducing morphine tolerance and withdrawal.

DOI 10.1101/2025.02.03.636278

mouseexperimental assay

𝕏 PostBluesky

Molecular BiologyBiomoleculesPeer-reviewedDec 25, 2024

G protein-coupled receptor 17 inhibits glucagon-like peptide-1 secretion via a Gi/o-dependent mechanism in enteroendocrine cells

Jason Michael Conley, Alexander Jochim, Carmella Evans‐Molina…·Hongxia Ren

This study investigates how GPR17 inhibits GLP-1 secretion in enteroendocrine cells through Gi/o-dependent signaling, using pharmacological and genetic approaches.

9 citations

mouseexperimental assay

𝕏 PostBluesky

NeuroscienceFrontiers in PharmacologyPeer-reviewedSep 2, 2022

Reduced activity of Adenylyl Cyclase 1 Attenuates Morphine Induced Hyperalgesia and Inflammatory Pain in Mice

Kayla Johnson, Alexis Doucette, Alexis Edwards…·Amanda H. Klein

This study shows reducing Adenylyl Cyclase 1 activity decreases morphine-induced hyperalgesia and inflammatory pain in mice without affecting morphine's analgesic effects.

8 citations

mouseexperimental assay

𝕏 PostBluesky