Inhibition of adenylyl cyclase 1 (AC1) and exchange protein directly activated by cAMP (EPAC) restores ATP-sensitive potassium (KATP) channel activity after chronic opioid exposure
Amanda H. Klein, Sabbir Alam, Kayla Johnson, Christian Kriner, Brie Beck, Bethany Theresa Nelson, Cassidy Hill, Belle Meyer, Jonas Mellang, Val J. Watts
This study shows that inhibiting AC1 and EPAC restores KATP channel activity after chronic opioid exposure, reducing morphine tolerance and withdrawal.
bioRxiv · Feb 3, 2025 · PreprintNeuroscience