Actin-related ACTL8 localizes to the nucleus and modulates locus-specific transcription through chromatin regulation
Nuria Cortes-Silva, Sanjana Banerjee, Kristen Dominique Amarillo, Sahiti Peddibhotla, Isabel Mejia Natividad, Betta Chopard, Christopher B. Geyer, Janet M. Young, Sandipan Brahma, Courtney M. Schroeder
This study identifies ACTL8 as a nuclear actin-related protein that modulates transcription through interaction with KDM5B, affecting migration pathways in cancer cells.
bioRxiv · Aug 24, 2026 · PreprintCell Biology