Minimal effective dose of telacebec administered orally in a murine model of leprosy
Aurélie Chauffour, Charlotte Avanzi, Alexandre Godmer, Corentin Poignon, Natalya V. Serbina, Emmanuelle Cambau, Bettina Broeckling, Josepg Himelspach, John Anderson, Nicolas Véziris, Alexandra Aubry
This study determines the minimal effective oral dose of telacebec against M. leprae in a mouse model, finding 20 mg/kg achieves complete bacterial clearance.
bioRxiv · Jun 5, 2026 · PreprintMicrobiology