This study evaluates how sex, age, and mouse strain affect M. abscessus infection progression using a beads model, finding BALB/cJRJ mice show more sustained infection with less variability.

Microbiology Spectrum · Oct 27, 2026Peer-reviewedMicrobiology

Minimal effective dose of telacebec administered orally in a murine model of leprosy

Aurélie Chauffour, Charlotte Avanzi, Alexandre Godmer, Corentin Poignon, Natalya V. Serbina, Emmanuelle Cambau, Bettina Broeckling, Josepg Himelspach, John Anderson, Nicolas Véziris, Alexandra Aubry

This study determines the minimal effective oral dose of telacebec against M. leprae in a mouse model, finding 20 mg/kg achieves complete bacterial clearance.

bioRxiv · Jun 5, 2026 · PreprintMicrobiology

A Murine Model of Mycobacterium abscessus Encapsulated in Alginate-Beads: Advancing Toward a Chronic Infection Model

Maya Rima, Aurélie Chauffour, Régis Tournebize, Corentin Poignon, Sarah Wong, Thi Cuc Mai, Maria Bitar, Romina Mehrabdollahi, Noël Zahr, Thibaud Coradin, Alexandra Aubry, Nicolas Véziris

This paper develops a murine model of Mycobacterium abscessus infection using alginate-encapsulated bacteria, showing slower clearance and increased dissemination, and evaluates antibiotic efficacy against encapsulated versus free bacteria.

bioRxiv · Apr 26, 2026 · PreprintMicrobiology

Evaluation of the role of whiB6 and kdpDE in the dominant multidrug resistant clone Mycobacterium tuberculosis B0/W148

Isabelle Bonnet, Mickael Orgeur, Florence Brossier, Fadel Sayes, Wafa Frigui, Jan Madacki, Hugo Varet, Aurélie Chauffour, Alexandra Aubry, Nicolas Véziris, Wladimir Sougakoff, Roland Brosch, Régis Tournebize

This study investigates two mutations in M. tuberculosis B0/W148 clone, finding they do not impair growth or virulence but alter transcriptional profiles.

Microbiology Spectrum · May 22, 2025Peer-reviewedMicrobiology