This study evaluates how sex, age, and mouse strain affect M. abscessus infection progression using a beads model, finding BALB/cJRJ mice show more sustained infection with less variability.

Microbiology Spectrum · Oct 27, 2026Peer-reviewedMicrobiology

Emergence of plasmid-borne erm(55)-associated macrolide resistance in Mycobacterium chelonae and other rapidly-growing non-tuberculous mycobacteria in Europe

Camille Allam, Yassine Charmat, Salim Agsous, Zeina Awad, Théo Fouchet, Lilou Goncalves, Nour Ben Salem, Corentin Poignon, Faïza Mougari, Nicolas Véziris, Emmanuelle Cambau

The paper identifies plasmid-borne erm(55) macrolide resistance in M. chelonae and other RGM in Europe, showing inducible resistance and genetic similarity to known plasmids.

bioRxiv · Jul 9, 2026 · PreprintMicrobiology

Minimal effective dose of telacebec administered orally in a murine model of leprosy

Aurélie Chauffour, Charlotte Avanzi, Alexandre Godmer, Corentin Poignon, Natalya V. Serbina, Emmanuelle Cambau, Bettina Broeckling, Josepg Himelspach, John Anderson, Nicolas Véziris, Alexandra Aubry

This study determines the minimal effective oral dose of telacebec against M. leprae in a mouse model, finding 20 mg/kg achieves complete bacterial clearance.

bioRxiv · Jun 5, 2026 · PreprintMicrobiology

A Murine Model of Mycobacterium abscessus Encapsulated in Alginate-Beads: Advancing Toward a Chronic Infection Model

Maya Rima, Aurélie Chauffour, Régis Tournebize, Corentin Poignon, Sarah Wong, Thi Cuc Mai, Maria Bitar, Romina Mehrabdollahi, Noël Zahr, Thibaud Coradin, Alexandra Aubry, Nicolas Véziris

This paper develops a murine model of Mycobacterium abscessus infection using alginate-encapsulated bacteria, showing slower clearance and increased dissemination, and evaluates antibiotic efficacy against encapsulated versus free bacteria.

bioRxiv · Apr 26, 2026 · PreprintMicrobiology