Molecular BiologybioRxivPreprint
Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets
Siming Liu, Israel J Wipf, Aditya Joglekar…·Yumi Imai
This study shows that PLIN2 regulates lipophagy in beta cells to prevent fatty acid accumulation in mitochondria, which impairs insulin secretion and mitochondrial function.
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