Lipid droplet protein Perilipin 2 is critical for the regulation of insulin secretion through beta cell lipophagy and glucagon expression in pancreatic islets
Siming Liu, Israel J Wipf, Aditya Joglekar, Aidan Freshly, Corinne E Bovee, Lucy Kim, Syreine Richtsmeier, Spencer J. Peachee, Shayla Kopriva, Anamika Vikram, Dalal El Ladiki, Fatma S. Ilerisoy, Beyza N. Ilerisoy, Gianna Sagona, Claudia Jun, , Yumi Imai
This study shows that PLIN2 regulates lipophagy in beta cells to prevent fatty acid accumulation in mitochondria, which impairs insulin secretion and mitochondrial function.
bioRxiv · Nov 17, 2024 · PreprintMolecular Biology