G quadruplex DNA facilitates a pervasive path to homologous recombination
Bhushan L Thakur, Priyanka Basak, Simran Khurana, Shalu Sharma, Yen-Hsi Lai, Tai Nguyen, Vijayalalitha Ramanarayanan, XianZhen Zhao, Pedro J. Batista, Travis H. Stracker, Philipp Oberdoerffer
This study identifies G-quadruplex DNA as a key factor in homologous recombination, showing that DHX36 suppresses G4-mediated HR and its loss enhances repair and promotes ALT.
bioRxiv · Jun 7, 2026 · PreprintMolecular Biology