Author
Johns Hopkins UniversityORCID 0000-0002-2484-1440Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Bhushan L Thakur, Priyanka Basak, Simran Khurana…·Philipp Oberdoerffer
This study identifies G-quadruplex DNA as a key factor in homologous recombination, showing that DHX36 suppresses G4-mediated HR and its loss enhances repair and promotes ALT.
Tae-Hee Lee, Colina X. Qiao, Vladislav Kuzin…·Philipp Oberdoerffer
The paper identifies macroH2A1 splicing as a regulator of TOP1 activity and shows its impact on cancer vulnerability to TOP1 inhibitors.
Motoshi Hayano, Jae-Hyun Yang, Michael S. Bonkowski…·David A. Sinclair
The paper shows that DNA double-strand breaks induce epigenomic changes that accelerate the aging clock in mammals.
Jae-Hyun Yang, Patrick T. Griffin, Daniel L. Vera…·David A. Sinclair
The paper shows that inducing DNA breaks accelerates aging-related chromatin changes and loss of cell identity in mammals.