Cannabinoid CB2R regulates T cell gut-homing in preclinical Crohns model.
Robert S. Leddy, Cinthia L. Hudachek, Hannah M Phelan, Billy P Egan, Carol M. Aherne, Julián Romero, Cece Hillard, Paul Jedlicka, Colm B. Collins
This study shows that CB2R signaling promotes T cell gut-homing in a preclinical Crohn's model by enhancing integrin 4β7 expression and transmigration across gut endothelial barriers.
bioRxiv · Sep 5, 2025 · PreprintImmunology