Julián Romero

Glycosylation of anandamide and other bioactive N-acylethanolamines in mammalian cells and tissues

The paper identifies NAE glycosylation as a metabolic pathway that links endocannabinoid metabolism to lysosomal dysfunction and inflammation.

Cannabinoid CB2R regulates T cell gut-homing in preclinical Crohns model.

This study shows that CB2R signaling promotes T cell gut-homing in a preclinical Crohn's model by enhancing integrin 4β7 expression and transmigration across gut endothelial barriers.

Cannabinoid CB2 receptors in primary sensory neurons are implicated in CB2 agonist-mediated suppression of paclitaxel-induced neuropathic nociception and sexually-dimorphic sparing of morphine tolerance

This study identifies primary sensory neurons as the cell type mediating anti-allodynic effects of CB2 agonists and reveals a sexually dimorphic sparing of morphine tolerance in male mice.

Peripheral sensory neuron CB2 cannabinoid receptors are necessary for both CB2-mediated antinociceptive efficacy and sparing of morphine tolerance in a mouse model of neuropathic pain

This study shows that CB2 receptors in peripheral sensory neurons are essential for the antinociceptive effects of CB2 agonists and their ability to reverse morphine tolerance in a neuropathic pain model.