A Next Generation Connectivity Map: L1000 Platform And The First 1,000,000 Profiles
Aravind Subramanian, Rajiv Narayan, Steven M. Corsello, David D. Peck, Ted Natoli, Xiaodong Lü, Joshua Gould, John F. Davis, Andrew A. Tubelli, Jacob K. Asiedu, David L. Lahr, Jodi Hirschman, Zihan Liu, Melanie K. Donahue, Bina Julian, , Todd R. Golub
The paper introduces the L1000 platform, a high-throughput gene expression profiling method, and reports 1.3 million perturbational profiles expanding the Connectivity Map for drug mechanism discovery and functional annotation.
Cell · Nov 1, 2017Peer-reviewedGenomics