Function of FMRP domains in regulating distinct roles of neuronal protein synthesis
Michelle Ninochka D’Souza, Sarayu Ramakrishna, Bindushree K Radhakrishna, Vishwaja Jhaveri, Sreenath Ravindran, Lahari Yeramala, Deepak Kumar Nair, Dasaradhi Palakodeti, Ravi Sondekoppa Muddashetty
This study identifies the functional roles of FMRP domains in translation regulation, showing that the C-terminus mediates ribosome binding and repression, while domain synergy is needed for granule formation and microtubule association.
Molecular Neurobiology · Oct 1, 2022Peer-reviewedNeuroscience