Michelle Ninochka D’Souza

Analysis of ribosomes from the Wild-type and FMR1 knockout human embryonic stem cells

This study analyzes ribosomes from wild-type and FMR1 knockout human embryonic stem cells, revealing altered translation rates and rRNA methylation patterns linked to FMRP's role in translational regulation.

Altering rRNA 2'O-methylation pattern during neuronal differentiation is regulated by FMRP

This study shows that FMRP regulates the 2O-methylation pattern of rRNA during neuronal differentiation, which affects protein synthesis and is disrupted in Fragile X Syndrome.

Function of FMRP domains in regulating distinct roles of neuronal protein synthesis

This study identifies the functional roles of FMRP domains in translation regulation, showing that the C-terminus mediates ribosome binding and repression, while domain synergy is needed for granule formation and microtubule association.