Ravi Sondekoppa Muddashetty

The paper uses ribosome profiling to study translation changes in synaptoneurosomes from rat cortical tissue after group 1 mGluR activation, showing increased translation of synaptic and ribosomal protein mRNAs.

This study shows that p21-activated kinase (PAK1) and Rab3a work together to repair plasma membrane damage caused by Aβ oligomers in neuronal cells.

This study analyzes ribosomes from wild-type and FMR1 knockout human embryonic stem cells, revealing altered translation rates and rRNA methylation patterns linked to FMRP's role in translational regulation.

This study shows that FMRP regulates the 2O-methylation pattern of rRNA during neuronal differentiation, which affects protein synthesis and is disrupted in Fragile X Syndrome.

The paper identifies APOE4 isoform-specific proteomic changes in neural precursor cells, revealing effects on RNA processing and cytoskeleton organization.

The paper identifies Golgi fragmentation as an early AD phenotype in neurons using stem cell and mouse models, showing its link to SORL1 variants and glycosylation changes.

This study identifies the functional roles of FMRP domains in translation regulation, showing that the C-terminus mediates ribosome binding and repression, while domain synergy is needed for granule formation and microtubule association.

The paper shows that NMDAR stimulation increases m6A levels and inhibits translation, linking m6A dynamics to neuronal translation regulation.

This study shows APOE4 disrupts calcium homeostasis in neurons, leading to sustained translation inhibition and impaired NMDAR signaling, while APOE3 causes a transient calcium response with recovery.

The paper identifies a distinct temporal expression of GW182 in neurons during postnatal development and shows its role in regulating dendritic growth through actin dynamics and LIMK1 expression.

The paper shows that mGluR and NMDAR regulate protein synthesis and ATP consumption in cortical neurons through distinct kinetics and AMPK-eEF2 signaling.

This study shows that reduced FMRP expression in Syngap1+/− mice leads to increased Syngap1 translation and altered eEF2 phosphorylation via NMDA receptor signaling.