EphA2 and Ephrin-A1 Use the Same Interface for Both in cis and in trans Interactions That Regulate Distinct Cell Signaling and Function
Soyeon Kim, Paul D. Toth, Wei J. Wang, Elena Seiradake, Xiaojun Shi, Bingcheng Wang
This paper identifies a shared interface for EphA2-ephrin-A1 cis and trans interactions, showing cis interactions inhibit trans signaling and contribute to oncogenesis.
bioRxiv · Jul 31, 2025 · PreprintBiophysics