Wei J. Wang

EphA2 and Ephrin-A1 Use the Same Interface for Both in cis and in trans Interactions That Regulate Distinct Cell Signaling and Function

This paper identifies a shared interface for EphA2-ephrin-A1 cis and trans interactions, showing cis interactions inhibit trans signaling and contribute to oncogenesis.

Human Vascularized Macrophage-Islet Organoids to Model Immune-Mediated Pancreatic β cell Pyroptosis upon Viral Infection

The paper develops vascularized macrophage-islet organoids to study immune-mediated β cell pyroptosis during viral infection and identifies TNFSF12-TNFRSF12A as a key mechanism.

Distinct 3D contacts and phenotypic consequences of adjacent non-coding loci in the epigenetically quiescent regions

The paper uses CRISPR screening guided by machine learning to identify essential non-coding hubs in epigenetically quiescent regions, revealing their distinct 3D contacts and phenotypic effects on cell growth and chromatin structure.

Young APPKI NL-G-F/NL-G-F mice display high-fat diet-induced metabolic disturbances and specific disorders associated with brain energy homeostasis.

This study shows that high-fat diet in early life causes metabolic disturbances in young AD mouse models but not neurological disorders.